ea0024p26 | (1) | BSPED2010
Eastwood L E
, Shepherd R M
, Kim J
, Skae M
, Banjeree I
, Hall C
, Clayton P
, Cosgrove K E
, Dunne M
Congenital Hyperinsulinism (CHI) is primarily a β-cell disorder with an incomplete pathogenesis. The purpose of this study was to generate in vitro models of the disease for the purposes of investigating the relationship between gene defect and β-cell development and function. We obtained post-operative resections of pancreatic tissue from four patients with hyperinsulinism. The tissue was collagenase treated and maintained in cell culture condit...